List of Chemicals Subject to Section 4 Test Orders

Since the 2016 Lautenberg Act amendments to TSCA, EPA has issued section 4 test orders for the following list of chemicals. Copies of the test orders, as well as EPA-reviewed studies or other data received in response to those test orders, can be found in the dockets linked below. Learn more about section 4 test orders.

Chemical Name	CAS Number	Chemical Uses	Docket Number	Test Order	Testing Required	Title of Study Received by EPA
3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctyl prop-2-enoate Synonym - 6:2 Fluorotelomer acrylate; 6:2 FTAc	CASRN 17527-29-6	Used as a reactant for plastics and resin manufacturing; manufacturing of textiles, apparel, and leather; and in other basic organic chemical manufacturing	EPA-HQ-OPPT-2024-0364	TSCA Section 4(a)(1) Test Order on 6:2 Fluorotelomer acrylate, (perfluorohexyl)ethyl acrylate (pdf) (1.78 MB)	Tier 1.1 - Test Required: Physical-Chemical Properties (OECD 102, OECD 103, OECD 104, OECD 105, OECD 111, OECD 117, OECD 121)  Tier 1.2 - Specific protocol may depend on results of the Tier 1.1. Health Effects (OECD 428, OECD 471, and one of the following: OECD 473, OECD 487, OECD 490)  Tier 2.1 - Test Required:  Health Effects (OECD 417) Environmental Fate (OECD 305)  Tier 2.2 - As required based on results of Tier 2.1.   Health Effects (OECD 417, OECD 422)
1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluoro-N-(2-hydroxyethyl)-N-methyloctane-1-sulfonamide Synonym - 2-(N-Methylperfluoro-1-octanesulfonamido)ethanol; NMeFOSE	24448-09-7	Aviation, imaging film, photoresist industries	EPA-HQ-OPPT-2023-0544	TSCA Section 4 Test Order for 2-(N-Methylperfluoro-1-octanesulfonamido)ethanol (NMeFOSE) (pdf) (1.36 MB)	Tier 1.1 - Test Required: Physical-Chemical Properties (OECD 102, OECD 103, OECD 104, OECD 105, OECD 111, OECD 122, OECD 112, OECD 115) Tier 1.2 - specific protocol may depend on results of the Tier 1.1. Physical-Chemical Properties (ISO 4311) Health Effects (OECD 428) Tier 1.3 – As required based on results of Tier 1.1. Physical-Chemical Properties (OECD 117) Environmental Fate (OECD 121) Tier 2.1 - Test Required: Health Effects (OECD 417) Environmental Fate (OECD 305) Tier 2.2 - As required based on results of Tier 2.1. Health Effects (OECD 417, OECD 422)
2,3,3,3-tetrafluoro-2-heptafluoropropoxy) propanoyl fluoride Synonym - Perfluoro(2-methyl-3-oxahexanoyl) fluoride; Hexafluoropropylene oxide-derived acyl fluoride; HFPO-DAF	2062-98-8	Used as a reactant in other basic organic chemical manufacturing	EPA-HQ-OPPT-2021-0903	TSCA Section 4(a)(1) Test Order for 2,3,3,3-tetrafluoro-2-heptafluoropropoxy) propanoyl fluoride, August 2023 (pdf) (1.05 MB)	Tier 1.1 - Test Required: Physical-Chemical Properties (OECD 102, OECD 103, OECD 104, OECD 105, OECD 122, OECD 111) Health Effects (OECD 437) Tier 1.2 - specific protocol may depend on results of the Tier 1.1. Physical-Chemical Properties (OECD 431, OECD 435) Health Effects (OECD 431, OECD 435, OECD 492B, OECD 473, OECD 487, OECD 490) Tier 1.3 – As required based on results of Tier 1.1. Health Effects (OECD 428, OECD 497, OECD 439)
6:2 Fluorotelomer sulfonamide betaine	34455-29-3	1) surface-active agent 2) as a fire-fighting foam agent	EPA-HQ-OPPT-2021-0897	TSCA Section 4(a)(1) Test Order for 6:2 Fluorotelomer sulfonamide betaine, June 2022 (pdf) (916.29 KB) October 2022 Correction to TSCA Section 4(a)(1) Test Order for 6:2 Fluorotelomer sulfonamide betaine (pdf) (1.75 MB)	June 2022: Physical-Chemical Properties (OECD 109; OECD 111; Aerodynamic Particle Size Distribution) and Health Effects (tier 1: Biosolubility, tier 2: OECD 417, OECD 403, OECD 412 Range-finding, OECD 412 subacute 28-day)
Anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone or C.I. Pigment Violet 29	81-33-4	1) As intermediate to make or adjust other perylene pigments 2) Incorporation in paints and coatings primarily in the automobile industry 3) Incorporation in plastic and rubber products primarily in automobiles and industrial carpeting 4) Merchant ink for commercial printing 5) Consumer watercolor and artistic color	EPA-HQ-OPPT-2020-0070	TSCA Section 4(a)(2) Test Order for Anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetrone or C.I. Pigment Violet 29, March 2020 (pdf) (5.03 MB)	March 2020: solubility testing and occupational exposure monitoring	Water solubility; Octanol solubility; Occupational Inhalation Exposure: Particulates Not Otherwise Regulated, Respirable
1,1-Dichloroethane	75-34-3	1) As intermediate in all other basic organic chemical manufacturing 2) As intermediate in all other chemical product and preparation manufacturing 3) Commercial laboratory chemical	EPA-HQ-OPPT-2018-0426	TSCA Section 4(a)(2) Test Order for 1,1-Dichloroethane, January 2021 (pdf) (2.28 MB)	January 2021: Environmental Hazard Testing (OECD 233), and facility-specific Occupational Exposure Testing (NIOSH Method 1003; OECD 428; Dermal Hand Wipe Sampling)
1,2-Dichloroethane	107-06-2	1) As intermediate in: Petrochemical manufacturing; Plastic material and resin manufacturing; All other basic organic chemical manufacturing 2) Incorporation in fuels and fuel additives: All other petroleum and coal products manufacturing 3) Incorporation in processing aids specific to petroleum production 4) Industrial adhesives and sealants 5) Industrial functional fluids (closed systems) as heat transferring agent 6) Industrial paste lubricants and greases 7) Industrial oxidation inhibitor in controlled oxidative chemical reactions 8) A component of industrial degreasing and cleaning solvents 9) Commercial plastic and rubber products 10) Commercial fuels and related products 11) Commercial laboratory chemical (e.g., reagent) 12) Commercial embalming agent 13) Consumer plastic and rubber products	EPA-HQ-OPPT-2018-0427	TSCA Section 4(a)(2) Test Order for 1,2-Dichloroethane, January 2021 (pdf) (2.28 MB) TSCA Section 4(a)(2) Test Order for 1,2-Dichloroethane, August 2022 (pdf) (849.95 KB)	January 2021: Facility-specific Occupational Exposure Testing (NIOSH Method 1003; OECD 428; Dermal Hand Wipe Sampling) March 2022: Environmental Hazard Testing (OECD 222)
1,1,2-Trichloroethane	79-00-5	1) Intermediate in: Plastic manufacturing; Petrochemical manufacturing; All other chemical product manufacturing 2) Industrial, commercial, and consumer adhesives and sealants 3) Commercial laboratory chemicals	EPA-HQ-OPPT-2018-0421	TSCA Section 4(a)(2) Test Order for 1,1,2-Trichloroethane, January 2021 (pdf) (2.28 MB) TSCA Section 4(a)(2) Test Order for 1,1,2-Trichloroethane, August 2022 (pdf) (864.84 KB)	January 2021: Environmental Hazard Testing (OECD 233), and facility-specific Occupational Exposure Testing (NIOSH Method 1003; OECD 428; Dermal Hand Wipe Sampling) March 2022: Environmental Hazard Testing (OECD 222; OCSPP 850.2300)
trans-1,2-Dichloroethylene	156-60-5	1) Reactant in plating agents and surface treating agents 2) Intermediate in chemical product and preparation manufacturing 3) Incorporation in solvents for cleaning or degreasing 4)Incorporation in solvents which become part of product formulation or mixture 5) Incorporation in adhesives and sealant chemicals 6) Incorporation in foam blowing additive 7) Incorporation in carrier solvent in adhesives, coatings, inks, lubricants, and silicones 8) Incorporation in articles: propellant and blowing agent in plastics product manufacturing; flexible polyurethane foam manufacturing 9) Industrial/commercial solvent: vapor degreaser 10) Industrial/commercial solvent: aerosol spray cleaner/degreaser 11) Industrial/commercial solvent: non-aerosol cleaner/degreaser 12) Industrial/commercial solvent: flux remover (liquid and aerosol) 13) Industrial/commercial cleaning and furnishing care products: spot cleaner; stain remover 14) Industrial/commercial functional fluids (open systems): smoothing fluid in additive manufacturing 15) Industrial/commercial anti-adhesive agent: mold release 16) Industrial/commercial solvents: urethane coatings 17) Industrial/commercial liquid and spray lubricants and greases, and penetrating lubricants 18) Industrial/commercial solvent-based adhesives and sealants; adhesive accelerant 19) Industrial/commercial functional fluids (closed systems): refrigerant 20) Industrial/commercial extraction solvent for thermoplastics 21) Industrial/commercial laboratory chemicals 22) Commercial and consumer propellants and blowing agents particularly in polyurethane foam building insulation 23) Commercial solvent for cleaning or degreasing: refrigerant flush 24) Consumer solvent for cleaning or degreasing: aerosol degreaser 25) Consumer adhesive accelerant	EPA-HQ-OPPT-2018-0465	TSCA Section 4(a)(2) Test Order for trans-1,2-Dichloroethylene, January 2021 (pdf) (2.31 MB) TSCA Section 4(a)(2) Test Order for trans-1,2-Dichloroethylene, August 2022 (pdf) (644.72 KB) Rescission of April 2022 TSCA Section 4(a)(2) Test Order for trans-1,2-Dichloethylene (pdf) (144.49 KB)	January 2021: Facility-specific Occupational Exposure Testing (NIOSH Method 1003; OECD 428; Dermal Hand Wipe Sampling) March 2022: Environmental Hazard Testing (OECD 219; OECD 233) and Consumer Exposure Testing (Short Term Emission 3, Source Characterization 1)
1,2-Dichloropropane	78-87-5	1) As intermediate in all other basic organic chemical manufacturing 2) Incorporation in all other chemical product and preparation manufacturing 3) Industrial processing aids, not otherwise listed 4) Commercial laboratory chemicals 5) Commercial cleaning and furnishing care product: all-purpose liquid spray cleaner; all-purpose waxes and polishes; all-purpose liquid cleaner/polish 6) Consumer cleaning and furnishing care product: all-purpose liquid spray cleaner; all-purpose waxes and polishes; all-purpose liquid cleaner/polish	EPA-HQ-OPPT-2018-0428	TSCA Section 4(a)(2) Test Order for 1,2-Dichloropropane, January 2021 (pdf) (2.29 MB) TSCA Section 4(a)(2) Test Order for 1,2-Dichloropropane, June 2022 (pdf) (436.63 KB) Rescission of April 2022 TSCA Section 4(a)(2) Test Order for 1,2-Dichloropropane (pdf) (144.16 KB)	January 2021: Environmental Hazard Testing (OECD 233), and facility-specific Occupational Exposure Testing (NIOSH Method 1013; OECD 428; Dermal Hand Wipe Sampling) March 2022: Environmental Hazard Testing (OECD 222; OCSPP 850.2200; OCSPP 850.2300), and Consumer Exposure Testing (Short Term Emission 3)
o-Dichlorobenzene	95-50-1	1) Processing as a reactant in all other chemical product and preparation manufacturing 2) Processing as an intermediate in all other basic organic chemical manufacturing 3) Incorporation as a solvent (which become part of product formulation or mixture) in plastic material and resin manufacturing; petroleum lubricating oil and grease manufacturing; all other chemical product and preparation manufacturing 4) Incorporation as processing aid in soap, cleaning compound, and toilet preparation manufacturing 5) Industrial solvents (which become part of product formulation or mixture) in Printing ink manufacturing; Paint and coating manufacturing; Synthetic dye and pigment manufacturing; All other basic organic chemical manufacturing 6) Industrial functional fluids (closed system): all other basic organic chemical manufacturing 7) Commercial ink and toners 8) Commercial coatings and paints, thinners, and paint removers 9) Commercial and consumer lubricants and greases (e.g., oil additives, degreasers, penetrant for pneumatic tools) 10) Commercial and consumer fuel additive for gasoline and diesel 11) Commercial and consumer continuous action air fresheners (including toilet/urinal deodorizers/fresheners) 12) Commercial laboratory chemicals 13) Commercial and consumer sheep-branding fluid; cleaning and furnishing care products 15) Consumer thinners (Products for cleaning brushes and tools used with overglazes)	EPA-HQ-OPPT-2018-0444	TSCA Section 4(a)(2) Test Order for o-Dichlorobenzene, January 2021 (pdf) (2.29 MB) TSCA Section 4(a)(2) Test Order for o-Dichlorobenzene, August 2022 (pdf) (913.69 KB)	January 2021: Environmental Hazard Testing (OCSPP 850.1735; OECD 233) and facility-specific Occupational Exposure Testing (NIOSH Method 1003; OECD 428; Dermal Hand Wipe Sampling) March 2022: Environmental Hazard Testing (OECD 233; OCSPP 850.1735) and Consumer Exposure Testing (Water-Air Emission 2; Short Term Emission 3)
p-Dichlorobenzene	106-46-7	1) As intermediate in plastic material and resin manufacturing; all other basic organic chemical manufacturing 2) Incorporation in intermediate in plastic material and resin manufacturing (including PPS, high performance plastics) 3) Incorporation in solvents ((which become part of product formulation or mixture) in Plastic material and resin manufacturing); Petroleum lubricating oil and grease manufacturing; All other chemical product and preparation manufacturing 4) Incorporation in Odor agents in Soap, cleaning compound, and toilet preparation manufacturing (e.g. urinal block, toilet/garbage deodorizers) 5) Incorporation into articles including plastic product manufacturing 6) Industrial solvents (which become part of product formulation or mixture) in synthetic dye and pigment manufacturing 7) Industrial functional fluids (closed system) in all other basic organic chemical manufacturing 8) Commercial continuous action air fresheners (including toilet/urinal/garbage deodorizers/fresheners), cleaning and furnishing care uses 9) Commercial lubricants and greases, degreasers (for oil additives for engines and pneumatic tools) 10) Commercial fuel additive for gasoline and diesel 11) Commercial laboratory chemicals and analytical uses, embalming uses 12) Commercial and consumer building and construction products e.g., plastic foam insulation, foam sealant 13) Consumer continuous action air fresheners (including toilet/urinal deodorizers/fresheners) 14) Consumer lubricants and greases (greases and oils for engines, gears and pneumatic tools) 15) Consumer fuel additive for gasoline and diesel	EPA-HQ-OPPT-2018-0446	TSCA Section 4(a)(2) Test Order for p-Dichlorobenzene, January 2021 (pdf) (2.3 MB) TSCA Section 4(a)(2) Test Order for p-Dichlorobenzene, August 2022 (pdf) (619.72 KB)	January 2021: Environmental Hazard Testing (OCSPP 850.1735; OECD 233), and facility-specific Occupational Exposure Testing (NIOSH Method 1003; OECD 428; Dermal Hand Wipe Sampling) March 2022: Environmental Hazard Testing (OECD 222)
Phosphoric acid, Triphenyl Ester	115-86-6	1) Incorporation in flame retardant used in all other chemical product and preparation manufacturing 2) Incorporation in flame retardant used in computer and electronic product manufacturing 3) Incorporation in flame retardant used in plastics material and resin manufacturing 4) Incorporation in plasticizer and flame retardant used in plastic product manufacturing 5) Incorporation in flame retardant used in rubber product manufacturing 6) Incorporation in flame retardant used in textiles, apparel, and leather manufacturing 7) Incorporation in flame retardant used in utilities 8) Incorporation in paint additive and coating additive used in paint and coating manufacturing 9) Incorporation in paint additive and coating additive used in paint and coating manufacturing 10) Incorporation in flame retardant used in furniture and related product manufacturing 11) Incorporation in flame retardant used in furniture and related product manufacturing 12) Incorporation in flame retardant used in operational fluids, maintenance fluids and semisolids, reactive fluids, and solids used in aerospace industry 13) Incorporation in flame retardant used in turbine engine oils in aviation 14) Incorporation in flame retardant used in turbine engine oils in non-aviation industries 15) Incorporation in flame retardant in lubricants and greases 16) Incorporation into article: flame retardant used in plastics material and resin manufacturing; plasticizer used in plastics product manufacturing; flame retardant used in furniture and related product manufacturing 17) Industrial/commercial paints and coatings 18) Industrial, commercial, and consumer plastic and rubber products not covered elsewhere 19) Industrial/commercial laboratory chemical 20) Industrial, commercial, and consumer lubricants and greases 21) Industrial/commercial operational fluids, maintenance fluids and semisolids, reactive fluids, and solids used in aerospace industry 22) Industrial/commercial turbine engine oils used in aviation 23) Industrial/commercial turbine engine oils used in non-aviation industries 24) Industrial, commercial, and consumer electrical and electronic products 25) Industrial, commercial, and consumer foam seating and bedding products 26) Industrial/commercial furniture and furnishings not covered elsewhere	EPA-HQ-OPPT-2018-0458	TSCA Section 4(a)(2) Test Order for Phosphoric acid, Triphenyl Ester (TPP), January 2021 (pdf) (2.32 MB) TSCA Section 4(a)(2) Test Order for Phosphoric acid, Triphenyl Ester, August 2022 (pdf) (888.15 KB)	January 2021: Environmental Hazard Testing (OCSPP 850.4400; OCSPP 850.4500; OECD 225; OECD 233; OECD 222), and facility-specific Occupational Exposure Testing (Inhalation Monitoring; Dermal Hand Wipe Sampling; OECD 428) March 2022: Environmental Hazard Testing (OCSPP 850.2200; OCSPP 850.2300)	OECD 225; EPA received acceptable existing information to fulfill need for OCSPP 850.4500
4,4’-(1-Methylethylidene)bis[2,6-dibromophenol]	79-94-7	1) Processing as a reactant for flame retardants in plastic material and resin manufacturing 2) Processing as a reactant for intermediates in other chemical product and preparation manufacturing 3) Incorporation into a formulation, mixture or reaction product for flame retardants: electrical equipment, appliance and component manufacturing; plastic material and resin manufacturing; plastics product manufacturing; computer and electronic product manufacturing 4) Incorporation into a formulation, mixture or reaction product for adhesive manufacturing 5) Incorporation as reactive flame retardant in printed circuit boards and semiconductor packages 6) Incorporation as reactive flame retardant in interior material for transportation equipment 7) Incorporation as additive flame retardant in plastic electronic enclosures 8) Electronic product recycling 9) Industrial, commercial, and consumer electrical and electronic products (e.g., reactive flame retardant) 10) Industrial/commercial laminate (e.g., reactive flame retardant in prepreg material for automotive and aviation interiors) 11) Industrial, commercial, and consumer electrical and electronic products (e.g., additive flame retardant in plastic enclosures) 12) Industrial/commercial building/construction materials not covered elsewhere 13) Industrial, commercial and consumer use in batteries (e.g., adhesive in lead-acid battery casings) 14) Industrial, commercial, and consumer furnishing, cleaning, and treatment/care products: fabric, textile, and leather products not covered elsewhere 15) Industrial/commercial laboratory chemical	EPA-HQ-OPPT-2018-0462	TSCA Section 4(a)(2) Test Order for 4,4’-(1-Methylethylidene)bis[2,6-dibromophenol] (TBBPA), January 2021 (pdf) (2.32 MB) TSCA Section 4 TSCA Section 4(a)(2) Test Order for 4,4’-(1-Methylethylidene)bis[2,6-dibromophenol](TBBPA), August 2022 (pdf) (855.42 KB)	January 2021: Environmental Hazard Testing (OCSPP 850.4400; OECD 225; OECD 233), and facility-specific Occupational Exposure Testing (Inhalation Monitoring; Dermal Hand Wipe Sampling; OECD 428) March 2022: Consumer Exposure Testing (Source-Dust 6; Migration-Sweat 9)	EPA received acceptable existing information to fulfill need for OECD 233 & OECD 225
Trifluoro(trifluoromethyl)oxirane (HFPO)	428-59-1	1) as a reactant for plastics material and resin manufacturing 2) in other basic organic chemical manufacturing	EPA-HQ-OPPT-2021-0910	TSCA Section 4(a)(1) Test Order for Trifluoro(trifluoromethyl)oxirane, January 2023 (pdf) (648.96 KB)	January 2023: Physical-Chemical Properties (OECD 111) and Health Effects (tier 1: In vitro Respiratory Tract Epithelial Toxicity, Gargas, et al. tier 2: OECD 416, OECD 426, OECD 424, OECD 463)