Acute-to-Chronic Estimation (ACE) with Time-Concentration-Effect Models Software

ICE and ACE were developed by the U.S. EPA in collaboration with other federal agencies, industry, and universities to address data gaps in species sensitivity and reduce reliance on uncertainty factors in ecological risk assessment.

The Acute-to-Chronic Estimation (ACE) with Time-Concentration-Effect Models software allows prediction of chronic toxicity from acute toxicity datasets. ACE uses linear regression and accelerated life testing to predict no-effect and low-effect concentrations for chronic mortality.