Generating ToxCast Data: Chemical Coverage
A complete list of chemicals included within ToxCast’s invitrodb, by version, are available on the on the CompTox Chemicals Dashboard.
ToxCast Chemical Library
EPA’s ToxCast research effort includes a chemical library of approximately 4,400 unique chemicals (as of December 2017). The library includes a broad range of chemicals with potential for human and ecosystem exposure which have heightened regulatory concern yet are lacking data on potential health effects of these chemicals.
The chemical library is organized into three phases. In 2007, Phase I was launched, screening 310 chemicals (mostly pesticides) across hundreds of assay endpoints. Phase II data increased the chemical inventory to about 1,800 chemicals. In 2014, Phase III was initiated, increasing the library to over 4,500 chemicals. Following Phase III, the ToxCast program has included data from more focused screening efforts rather than continuing to screen only in chemical blocks by phase.
More Information on ToxCast Chemicals
- ToxCast Chemical Library
- Chemical Procurement Workflow: Overview on the workflow EPA follows to select chemicals, procure chemicals, register chemicals, conduct a quality review of the chemicals, and prepare the chemicals for ToxCast.